Group Members

Group Leader

Alexi Nott

Alexi Nott

Group Leader

Education:
Univerity of Bath, MBiochem
University College London, Ph.D.

Email: a.nott@imperial.ac.uk

Bio: Alexi completed his PhD at University College London investigating the function of epigenetic regulators during brain development. During his postdoctoral fellowship at MIT he investigated the role of epigenetics in postnatal development and autism-related behaviors. His research at the University of California, San Diego examined epigenetic mechanisms underlying age-related brain disorders and he identified microglia as associated with the genetic risk of Alzheimer’s disease.

Research:
Alexi's research utilizes nuclei isolation methods and genome-wide sequencing approaches to examine the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions will employ CRIPSR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi will examine the epigenome of the human brain to understand how genetic variation contributes to age-related brain disorders.

Postdoctoral Researchers

Postdoctoral Researcher

Looking for motivated postdoc researchers

Online application here

Job Description:
We are seeking an outstanding post-doctoral researcher interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. Experience of genomic approaches, preferentially those pertaining to chromatin biology, is desirable and a background in molecular neuroscience would be advantageous.

Email question to: a.nott@imperial.ac.uk

Research Technician

Research Technician

Seeking to hire a research technician

Online application here

Job Description:
We have a position available to provide technical support in molecular and cellular neuroscience for projects focused on neuroepigenomics of brain homeostasis and disease. Practical experience in genomic methods and biological tissue management would be preferrable.

Email question to: a.nott@imperial.ac.uk