Group Members

Group Leader

Alexi Nott

Alexi Nott

Group Leader and UK DRI Fellow

Univerity of Bath, MBiochem
University College London, Ph.D.


Bio: Alexi completed his PhD at University College London investigating the function of epigenetic regulators during brain development. During his postdoctoral fellowship at MIT he investigated the role of epigenetics in postnatal development and autism-related behaviors. His research at the University of California, San Diego examined epigenetic mechanisms underlying age-related brain disorders and he identified microglia as associated with the genetic risk of Alzheimer’s disease.

Research: Alexi's research utilizes nuclei isolation methods and genome-wide sequencing approaches to examine the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions will employ CRIPSR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi will examine the epigenome of the human brain to understand how genetic variation contributes to age-related brain disorders.

Postdoctoral Researchers

Postdoctoral Researcher

Looking for motivated postdoc researchers

Job Description:
We are seeking outstanding post-doctoral researchers interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. Experience of genomic approaches, preferentially those pertaining to chromatin biology, is desirable and a background in molecular neuroscience would be advantageous.

Email enquiries to:

Postgraduate Students

Lucy Bedwell

Lucy Bedwell

Translational Neuroscience MSc student

Bio: I am a master’s student in the Translational Neuroscience programme completing my project under the supervision of Dr. Alexi Nott. I previously graduated from the University of Nottingham where my final year research project involved examining the association of atypical language laterality with Schizotypal personality disorder. My master’s research will focus on nuclear factors associated with modulation of microglia disease-associated states using a mouse model of inflammation. In the future I hope to pursue my research interests further by completing a PhD in the field of inflammation and neurodegenerative disease.