Group Members

Group Leader

Alexi Nott

Alexi Nott

Group Leader and Fellow | UK DRILecturer | Imperial College LondonLGBTQ+ Champion | Brain Sciences

Education:
Univerity of Bath, MBiochem
University College London, Ph.D.

Email: a.nott@imperial.ac.uk

Bio: Alexi completed his PhD at University College London investigating the function of epigenetic regulators during brain development. During his postdoctoral fellowship at MIT he investigated the role of epigenetics in postnatal development and autism-related behaviours. His research at the University of California, San Diego examined epigenetic mechanisms underlying age-related brain disorders and he identified microglia as associated with the genetic risk of Alzheimer’s disease.

Research: Alexi's research utilizes nuclei isolation methods and genome-wide sequencing approaches to examine the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions will employ CRISPR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi will examine the epigenome of the human brain to understand how genetic variation contributes to age-related brain disorders.

Postdoctoral Researchers

Reuben Yaa

Reuben Yaa

UK DRI Research Associate

Bio: I am a Research Associate in the Nott group at the UK Dementia Research Institute at Imperial. I joined the lab after completing my PhD, which was funded by the Darwin Trust of Edinburgh studentship at King’s College London in the lab of Dr. Fiona Wardle. My PhD research project characterised cis-regulatory elements of TBXT, a transcription factor involved in metastatic cancers in lung, prostate and breast tissue, and in a rare cancer of the spinal column called chordoma. During my PhD, I visited the lab of Dr. Gómez Skarmeta at Andalusian Centre for Developmental Biology (CABD) in Seville, Spain on an European Molecular Biology Organisation (EMBO) fellowship for extended training on assays and tools used in gene regulation studies. Prior to starting my PhD, I worked as a Research Assistant in the lab of Prof. Faith Osier at Kenya Medical Research Institute (KEMRI), Wellcome Trust, Kilfi, where I led a recombinant protein expression and protein micro-array facility in a malaria study. My current project in the Nott group exploits different chromatin and epigenetic assays to characterise enhancer maps associated with neurodegenerative disease risk variants.

Email: r.yaa@imperial.ac.uk

Philippa Wells

Philippa Wells

UK DRI Research Associate

Bio: I am a Research Associate in the Nott group at Imperial, within the department of Brain Sciences, part of the UK Dementia Research Institute. I completed my PhD in Genetic Epidemiology, entitled “Host genetic factors underlying the link between the microbiome and rheumatoid arthritis”, with the Department of Twin Research at King’s College London, supervised by Claire Steves and Frances Williams. I obtained my degree, BSc (Hons.) Medical Sciences from the University of Exeter. During my degree I undertook a research year at the University of Bristol and the Bristol Brain Bank investigating the role of the renin angiotensin system in Alzheimer’s disease; This work sparked my interest in Alzheimer’s disease. Following my PhD I continued at KCL as a Research Associate, before joining Imperial College London in the lab of Abbas Dehgan affiliated with the UKDRI to characterise the metabolomic profile of Alzheimer’s disease. In the Nott group, my focus will be investigating the transcriptome and epigenome of the Alzheimer’s disease brain. My aim moving forward is to continue to contribute to the field of Alzheimer’s disease research.

Email: pmwells@ic.ac.uk

PhD Students

Janis Transfed

Janis Transfeld

UK DRI PhD Student

Bio: I am a PhD student in the Nott lab at the UK Dementia Research Institute and I am enrolled in the Clinical Medicine Research (Brain Sciences) program at Imperial College London. Before I joined the lab, I completed my B.Sc. in Applied Biology and M.Sc. in Biomedical Sciences from the University of Applied Sciences Bonn-Rhein-Sieg, Germany. As part of this, I performed a research project for my bachelor in the Institute of Molecular Psychiatry at the University of Bonn on the characterization of a glia-specific knock-out mouse line, hereby developing a keen interest for the field of neurological diseases. To complete my M.Sc., I investigated molecular processes occurring during osteogenesis using induced pluripotent stem cells (iPSCs). In the Nott lab I plan to integrate my experience on working with iPSCs to elucidate functional relevance of neurodegenerative disease-associated risk variants.

Email: j.transfeld21@imperial.ac.uk

Kevin Ziegler

Kevin Ziegler

UK DRI PhD Student

Bio: I am a graduate student in the Department of Brain Sciences at Imperial College London. Prior to starting my PhD in the Nott lab, I completed both my Bachelor's and Master's degrees in Biotechnology at Hochschule Mannheim, University of Applied Sciences. During this time, I took the opportunity to gain research experience at the Broad Institute of Harvard and MIT, the Centro de Investigaciones Biologicas, and most recently at the German Cancer Research Center (DKFZ). Of all the knowledge I gained during this time, neurological questions and the application of single cell sequencing technologies excited me the most. For my PhD, I am particularly interested in applying the latest epigenome based single cell technologies to uncover the well-kept secrets of dementia.

Email: k.ziegler21@imperial.ac.uk

Research Technician

Lucy Bedwell

Lucy Bedwell

Research Technician

Bio: I am a Research Technician following completion of my master’s in the Translational Neuroscience programme under the supervision of Dr. Alexi Nott. I previously graduated from the University of Nottingham where my final year research project involved examining the association of atypical language laterality with Schizotypal personality disorder. My research focuses on nuclear factors associated with modulation of microglia disease-associated states using a mouse model of inflammation. In the future I hope to pursue my research interests further by completing a PhD in the field of inflammation and neurodegenerative disease.

Email: lucy.bedwell20@imperial.ac.uk

Postgraduate Students

Myrto Mavrotas

Myrto Mavrotas

MRes Experimental Neuroscience student

Bio: I am a psychiatrist by background who has taken a year away from clinical training in order to do my MRes In Experimental Neuroscience at Imperial. I will work on my second research project in the lab of Dr Alexi Nott. I am a graduate of King's College London (MBBS) and Imperial College (BSc in Medical Sciences - Haematology). Having developed an interest in the role of neuroinflammation in neuropsychiatric diseases during my clinical work I am confident that, under the supervision of Dr Nott, I will be able to learn a lot about the molecular and biochemical basis of neuroinflammation. I hope I will be able to pursue my specific interests further at a doctoral level sometime in the near future.

Email: myrto.mavrotas10@imperial.ac.uk

Aydan Askarova

Aydan Askarova

MSc Applied Genomics student

Bio: I am a master’s student in Applied Genomics at Imperial College London. For my research project I will be working under the supervision of Dr Alexi Nott on characterising roles of repressive elements in glial cells to understand brain disorders. Prior to my master’s studies, I completed my BSc in Biology at Queen Mary University of London. My final year BSc dissertation focused on how politics influence comprehension of Covid19 in general population of the USA for which I used raw data from Twitter.

Email: aydan.askarova21@imperial.ac.uk

Alumni

Natalie Figueredo Burgos

Natalie Figueredo Burgos

MRes Experimental Neuroscience student

Bio: I am master’s student in the Experimental Neuroscience programme at Imperial College London. I will be completing my first project under the supervision of Dr. Alexi Nott. Before I joined Imperial, I completed my BSc in Neuroscience at the University of Leeds. My final year project involved evaluating the temporal characteristics of neurogenesis in the postnatal mammalian olfactory bulb.

Email: n.figueredo-burgos21@imperial.ac.uk