Research vision
The Nott group studies how the epigenome and chromatin architecture shape cell type gene expression programmes in the healthy brain and during ageing and disease. Using human genetics alongside epigenomic profiling of patient-derived brain tissue and stem cell-derived models, we ask why particular brain cell types — from microglia to the vascular cells of the brain — are especially susceptible to ageing-related brain conditions such as Alzheimer's disease and small vessel disease, and how this susceptibility changes across the human life course.
Our group is situated in the UK Dementia Research Institute (DRI) and the Department of Brain Sciences at Imperial College London. The UK DRI is comprised of seven centers embedded at six major universities in the UK, which aims to bring together expertise to find new treatments for dementia. Our location is easily accessible to world-class research institutes within London and beyond, which has provided a unique setting to do research!